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pentobarbital will decrease the level or impact of capivasertib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Solid or reasonable CYP3A inducers lower capivasertib exposure, which may lessen efficacy.pentobarbital will lower the extent or impact of diclofenac by affecting hepatic enzyme CYP2C9/ten metabolism